*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : FB3325000
CHEMICAL NAME : Carbamic acid, isopropyl-,
2-(hydroxymethyl)-2-methylpentyl ester carbamate
(ester)
CAS REGISTRY NUMBER : 78-44-4
BEILSTEIN REFERENCE NO. : 1791537
REFERENCE : 4-04-00-00520 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C12-H24-N2-O4
MOLECULAR WEIGHT : 260.38
WISWESSER LINE NOTATION : ZVO1X3&1&1OVMY1&1
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Apesan
* Arusal
* Atonalyt
* Brianil
* Calenfa
* Caprodat
* Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl
isopropylcarbamate
* Carbamic acid, ester with 2-methyl-2-propyl-1,3-propanediol
isopropylcarbamate
* Carisol
* Carisoma
* Carisoprodate
* Carisoprodatum
* Carisoprodol
* Carlsoma
* Carlsoprol
* Carsodal
* Carsodol
* CB 8019
* Diolene
* Domarax
* Flexal
* Flexartal
* Isobamate
* Isomeprobamate
* Isopropylcarbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl
carbamate
* Isopropyl meprobamate
* N-Isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate
* Isoprotan
* Isoprotane
* Izoprotan
* Mediquil
* (1-Methylethyl)carbamic acid
2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester
* 2-Methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate
* Mioartrina
* Miolisodal
* Mioril
* Mioriodol
* NCI-C56235
* Nospasm
* 1,3-Propanediol, 2-methyl-2-propyl-, carbamate isopropylcarbamate (ester)
* Rela
* Relasom
* Sanoma
* Sch 7307
* Skutamil
* Somadril
* Somalgit
* Somanil
* Stialgin
* Tonolyt isopropyl meprobamate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1320 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 127,66,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 127,66,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3,
1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year:
2,17,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1800 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 12,340,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 238,92,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 165 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 127,66,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 124 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - rigidity (including catalepsy)
REFERENCE :
IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8,
1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year:
5,305,1966
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 126 gm/kg/15W-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,197,1992
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 277 gm/kg
SEX/DURATION : male 15 week(s) pre-mating - 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
24,132,1995
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4826
No. of Facilities: 62 (estimated)
No. of Industries: 2
No. of Occupations: 7
No. of Employees: 2431 (estimated)
No. of Female Employees: 1194 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***