*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EZ0875000
CHEMICAL NAME           : Carbamic acid, butyl-, ester with
                          2-(hydroxymethyl)-2-methylpentyl carbamate
CAS REGISTRY NUMBER     : 4268-36-4
BEILSTEIN REFERENCE NO. : 1970468
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C13-H26-N2-O4
MOLECULAR WEIGHT        : 274.41
WISWESSER LINE NOTATION : ZVO1X3&1&1OVM4
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Benvil
   * N-n-Butyl-2-methyl-2-propyl-1,3-propanediol dicarbamate
   * N-Butyl-2-methyl-2-propyl-1,3-propanediol dicarbamate
   * Carbamic acid, butyl-, 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl  
   ester
   * Carbamic acid, butyl-, 2-(hydroxymethyl)-2-methylpentyl ester, carbamate
   * Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl butylcarbamate
   * Carbamic acid, ester with 2-methyl-2-propyl-1,3-propanediol  
   butylcarbamate
   * Depran
   * Effisax
   * 2-(Hydroxymethyl)-2-(methylpentyl) butylcarbamate carbamate
   * Idalene
   * 2-Methyl-2-propyl-1,3-propanediol butylcarbamate carbamate
   * 2-Methyl-2-propyltrimethylene butylcarbamate carbamate
   * Nospan
   * 1,3-Propanediol, 2-methyl-2-propyl-, butylcarbamate carbamate
   * Reposan
   * Solacen
   * Solacin
   * Tibamato
   * Tibamax
   * Tybamate
   * Tybatran
   * W 713
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 18 mg/kg/D
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - hallucinations, distorted perceptions
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JAGSAF Journal of the American Geriatrics Society.  (American Geriatrics
   Soc., Inc., Box 465, Hanover, PA 17331)  V.1-    1953-
   Volume(issue)/page/year: 12,1066,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1040 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,418,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 328 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   19,93,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 181,68,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 482 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   19,93,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 254 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,418,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   IJNEAQ International Journal of Neuropharmacology.  (New York, NY)  V.1-8,
   1962-69.  For publisher information, see NEPHBW.  Volume(issue)/page/year:
   5,305,1966
 
                            *** END OF RECORD ***