*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EX1650000
CHEMICAL NAME           : Camptothecin, sodium salt
CAS REGISTRY NUMBER     : 25387-67-1
LAST UPDATED            : 199706
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H18-N2-O5.Na
MOLECULAR WEIGHT        : 389.39
WISWESSER LINE NOTATION : T F6 D6 C566 BN HVO LVN NHT&&&&J GQ G2
COMPOUND DESCRIPTOR     : Drug
                          Human
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Camptothecine sodium
   * NSC-100880
   * 21,22-Secocamptothecin-21-oic acid, monosodium salt
   * Sodium camptothecin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 2500 ug/kg/7D-I
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - thrombocytopenia
   Blood - changes in cell count (unspecified)
REFERENCE :
   CCROBU Cancer Chemotherapy Reports, Part 1.  (Washington, DC)  V.52(6)-59,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   56,515,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PMDCAY Progress in Medical Chemistry.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1961- Volume(issue)/page/year:
   9,1,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 151 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTKRDX Gan to Kagaku Ryoho.  Cancer and Chemotherapy.  (1-8-9 Yaesu,
   Chuo-ku, Tokyo 103, Japan) V.1-    1974-  Volume(issue)/page/year:
   14,850,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 57 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PMDCAY Progress in Medical Chemistry.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1961- Volume(issue)/page/year:
   9,1,1973
 
                            *** END OF RECORD ***