*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EW8750000
CHEMICAL NAME           : Calotropin
CAS REGISTRY NUMBER     : 1986-70-5
LAST UPDATED            : 199210
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C29-H40-O9
MOLECULAR WEIGHT        : 532.69
WISWESSER LINE NOTATION : L E5 B666TJ AVH DQ E1 IQ F- DT5OV EHJ& O- BT6O CVTJ
                          DQ EQ F1
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Pecilocerin A
   * Pekilocerin A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9800 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   41CIAR "Effects of Poisonous Plants on Livestock, Proceedings of a Joint
   U.S.-Australian Symposium on Poisonous Plants, Logan, UT, 1977," Keeler,
   R.F., et al. eds., New York, Academic Press, Inc., 1978
   Volume(issue)/page/year: -,273,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 103 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 74,223,1942
 
                            *** END OF RECORD ***