*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EU4167000
CHEMICAL NAME           : Butyrophenone,
                          4'-fluoro-4-(1,2,3,4,6,7,12,12a-octahydropyrazino(1',
                          2':1,6)pyrido(3,4-b) indol-2-yl)-
CAS REGISTRY NUMBER     : 41510-23-0
LAST UPDATED            : 199107
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C24-H26-F-N3-O
MOLECULAR WEIGHT        : 391.53
WISWESSER LINE NOTATION : T D6 B656 FN IN LMTT&&J F3VR DF
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Centbutindole
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   3,803,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 17,312,1982
 
                            *** END OF RECORD ***