*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ES7110000
CHEMICAL NAME : Butyric acid, 2-amino-4-(methylselenyl)-, DL-
CAS REGISTRY NUMBER : 2578-28-1
BEILSTEIN REFERENCE NO. : 1758204
REFERENCE : 4-04-00-03216 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 29
MOLECULAR FORMULA : C5-H11-N-O2-Se
MOLECULAR WEIGHT : 196.13
WISWESSER LINE NOTATION : QVYZ2-SE-1
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* (+-)-2-Amino-4-(methylseleno)butanoic acid
* Butanoic acid, 2-amino-4-(methylseleno)-, (+-)-
* (+-)-Selenomethionine
* Seleno-DL-methionine
* dl-Selenomethionine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10680 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 17,171,1980
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 19600 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
45,207,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 77035 ug/kg/31D-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Blood - other changes
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
32,217,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 84 mg/kg/6W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 27,263,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 314 mg/kg/14W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - pigmented or nucleated red blood cells
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 32,449,1991
** MUTATION DATA **
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
10,75,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
10,75,1980
*** REVIEWS ***
ACGIH TLV-TWA 0.2 mg(Se)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Se)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,224,1971
OSHA PEL (Gen Indu):8H TWA 0.2 mg(Se)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.2 mg(Se)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.2 mg(Se)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.2 mg(Se)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993
OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** END OF RECORD ***