*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ES7100000
CHEMICAL NAME : Butyric acid, 2-amino-4-(methylselenyl)-
CAS REGISTRY NUMBER : 1464-42-2
LAST UPDATED : 199712
DATA ITEMS CITED : 29
MOLECULAR FORMULA : C5-H11-N-O2-Se
MOLECULAR WEIGHT : 196.13
WISWESSER LINE NOTATION : QVYZ2-SE-1
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 2-Amino-4-(methylselenyl)butyric acid
* Methionine, seleno
* Selenomethionine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 108,437,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 22 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 2,383,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracervical
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 13 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 2,383,1981
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 7450 ug/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - somnolence (general depressed activity)
Gastrointestinal - nausea or vomiting
REFERENCE :
AJVRAH American Journal of Veterinary Research. (American Veterinary
Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
Volume(issue)/page/year: 34,1227,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 37 mg/kg/12W-C
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 19,836,1990
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 14710 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year:
4,183,1990
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 80 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,503,1989
*** REVIEWS ***
ACGIH TLV-TWA 0.2 mg(Se)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Se)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,224,1971
OSHA PEL (Gen Indu):8H TWA 0.2 mg(Se)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.2 mg(Se)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.2 mg(Se)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.2 mg(Se)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993
OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** END OF RECORD ***