*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EM9252420
CHEMICAL NAME           : 2-Butenoic acid, 2-methyl-,
                          7-((2,3-dihydroxy-2-(1-hydroxyethyl)-3-methyl-1-oxobu
                          toxy) methyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl
                          ester, hydrochloride
LAST UPDATED            : 198909
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H31-N-O7.Cl-H
MOLECULAR WEIGHT        : 433.98
COMPOUND DESCRIPTOR     : Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Echimidine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Vascular - other changes
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - hemorrhage
REFERENCE :
   FRBGAT Frontiers of Biology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1966- Volume(issue)/page/year:
   9,142,1968
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 20 umol/L
REFERENCE :
   ZEVBA5 Zeitschrift fuer Vererbungslehre.  (Berlin, Fed. Rep. Ger.) V.89-98,
   1958-66.  For publisher information, see MGGEAE. Volume(issue)/page/year:
   91,74,1960

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***