*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ES5222000
CHEMICAL NAME           : Butyramidoxime, 3-hydroxy-4-(alpha-naphthyloxy)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 35991-93-6
LAST UPDATED            : 198910
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C14-H16-N2-O3.Cl-H
MOLECULAR WEIGHT        : 296.78
WISWESSER LINE NOTATION : L66J BO1YQ1YZUNQ &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Bradyl
   * Butanimidamide, N,3-dihydroxy-4-(1-naphthalenyloxy)-, hydrochloride
   * Chlorhydrate de (naphthyloxy-1)-4 hydroxy-3 butyramidoxime
   * N,3-Dihydroxy-4-(1-naphthalenyloxy)butaninidamide hydrochloride
   * 3-Hydroxy-4-(1-naphthyloxy)butyramidoxime hydrochloride
   * LL 1530
   * Nadoxolol hydrochloride
   * 4-alpha-Naphthyloxy-3-hydroxy-butyramidoxim-hydrochlorid
   * 4-(alpha-Naphthyloxy)-3-hydroxybutyramidoxime hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Cardiac - other changes
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 4,163,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 4,163,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GWXXBX German Offenlegungsschrift Patent Document.  (U.S. Patent and
   Trademark Office, Foreign Patents, Washington, DC 20231)
   Volume(issue)/page/year: #2132113
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GWXXBX German Offenlegungsschrift Patent Document.  (U.S. Patent and
   Trademark Office, Foreign Patents, Washington, DC 20231)
   Volume(issue)/page/year: #2132113
 
                            *** END OF RECORD ***