*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ES0810000
CHEMICAL NAME           : 3-Butyn-2-ol, 2-methyl-
CAS REGISTRY NUMBER     : 115-19-5
BEILSTEIN REFERENCE NO. : 0635746
REFERENCE               : 4-01-00-02229 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C5-H8-O
MOLECULAR WEIGHT        : 84.13
WISWESSER LINE NOTATION : QX1&1&1UU1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-Butyn-3-ol, 3-methyl-
   * Dimethylacetylenecarbinol
   * Dimethylacetylenylcarbinol
   * Dimethylethynylcarbinol
   * Dimethylethynylmethanol
   * alpha,alpha-Dimethylpropargyl alcohol
   * 1,1-Dimethylpropargyl alcohol
   * 1,1-Dimethylpropynol
   * Ethynyldimethylcarbinol
   * 2-Hydroxy-2-methyl-3-butyne
   * MBY
   * 3-Methyl-butin-(1)-ol-(3)
   * 2-Methylbutyn-3-ol-2
   * 2-Methyl-3-butyn-2-ol
   * 3-Methyl-1-butyn-3-ol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 115,230,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(4),55,1987
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/m3
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(4),55,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1161 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 76,181,1956

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1058
       No. of Facilities: 67 (estimated)
       No. of Industries: 2
       No. of Occupations: 5
       No. of Employees: 3234 (estimated)
       No. of Female Employees: 2672 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***