*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EN0330000
CHEMICAL NAME           : 3-Buten-2-one, 4-phenyl-
CAS REGISTRY NUMBER     : 122-57-6
BEILSTEIN REFERENCE NO. : 0742046
REFERENCE               : 2-07-00-00287 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C10-H10-O
MOLECULAR WEIGHT        : 146.20
WISWESSER LINE NOTATION : 1V1U1R
COMPOUND DESCRIPTOR     : Drug
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Benzalaceton
   * Benzalacetone
   * Benzylidene acetone
   * 4-Phenyl-3-buten-2-one
   * Styryl methyl ketone
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 11,1021,1973
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1%/48H
REACTION SEVERITY       : Moderate
REFERENCE :
   JSCCA5 Journal of the Society of Cosmetic Chemists.  (Soc. of Cosmetic
   Chemists, 1995 Broadway, Suite 1701, New York, NY 10023)  V.1-    1947-
   Volume(issue)/page/year: 28,357,1977
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2031 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Vascular - regional or general arteriolar or venous dilation
   Skin and Appendages - hair
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0391-1194
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 19,617,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 112 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 19,617,1969

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83179
       No. of Facilities: 41 (estimated)
       No. of Industries: 3
       No. of Occupations: 5
       No. of Employees: 550 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83179
       No. of Facilities: 196 (estimated)
       No. of Industries: 7
       No. of Occupations: 10
       No. of Employees: 5458 (estimated)
       No. of Female Employees: 2178 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***