*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EM6000000
CHEMICAL NAME           : 2-Butenedioic acid, 2,3-dihydroxy-, (Z)-, compd. with
                          alpha,alpha,beta- trimethylbenzeneethanamine
CAS REGISTRY NUMBER     : 5789-70-8
LAST UPDATED            : 199307
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C11-H17-N.C4-H6-O6
MOLECULAR WEIGHT        : 313.39
WISWESSER LINE NOTATION : ZX1&1&Y1&R &QVYQYQVQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3-Butylamine, 3-methyl-2-phenyl-, tartrate
   * F 394
   * 2-Phenyl-3-methyl-3-butylamine tartrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 241 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 13,711,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 312 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 13,711,1963
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 480 mg/kg/12W-I
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 13,711,1963
 
                            *** END OF RECORD ***