*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EL9450000
CHEMICAL NAME : 2-Butanone, peroxide
CAS REGISTRY NUMBER : 1338-23-4
LAST UPDATED : 199712
DATA ITEMS CITED : 31
MOLECULAR FORMULA : C8-H16-O4
MOLECULAR WEIGHT : 176.24
WISWESSER LINE NOTATION : 1V2OO2V1
COMPOUND DESCRIPTOR : Tumorigen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Butanox LPT
* Butanox M 50
* Butanox M 105
* Chaloxyd MEKP-HA 1
* Chaloxyd MEKP-LA 1
* Esperfoam FR
* Ethyl methyl ketone peroxide
* FR 222
* HI-Point 90
* HI-Point 180
* HI-Point PD-1
* Kayamek A
* Kayamek M
* Ketonox
* Lucidol DDM 9
* Lucidol Delta X
* Lupersol DDA 30
* Lupersol DDM
* Lupersol Delta X
* Lupersol DNF
* Lupersol DSW
* MEK peroxide
* MEKPO
* Mepox
* Methyl ethyl ketone hydroperoxide
* Methyl ethyl ketone peroxide
* Methylethylketonhydroperoxide
* NCI-C55447
* Permek G
* Permek N
* Quickset Extra
* Quickset super
* RCRA waste number U160
* Sprayset MEKP
* Superox 46-710
* Thermacure
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3 mg
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
19,205,1958
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 480 mg/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of esophagus
Gastrointestinal - nausea or vomiting
Gastrointestinal - other changes
REFERENCE :
NCPBBY National Clearinghouse for Poison Control Centers, Bulletin. (U.S.
Department of Health, Education, and Welfare, Washington, DC)
Volume(issue)/page/year: Jan/Feb,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 484 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 ppm/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
165,201,1957
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 170 ppm/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
19,205,1958
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2033 mg/kg/7W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 273 mg/kg/7W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
19,205,1958
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 282 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67.
Discontinued. Volume(issue)/page/year: 3,193,1963
*** REVIEWS ***
ACGIH TLV-CL 1.5 mg/m3 (0.2 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-BELGIUM:STEL 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-DENMARK:STEL 1 mg/m3 JAN 1993
OEL-FINLAND:STEL 0.2 ppm (1.5 mg/m3);Skin JAN 1993
OEL-FRANCE:STEL 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-SWEDEN:STEL 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 ppm (1.5 mg/m3);STEL 0.2 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL ETHYL KETONE PEROXIDE-air:CL 0.2 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80105
No. of Facilities: 2226 (estimated)
No. of Industries: 29
No. of Occupations: 31
No. of Employees: 20053 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80105
No. of Facilities: 1879 (estimated)
No. of Industries: 23
No. of Occupations: 31
No. of Employees: 25827 (estimated)
No. of Female Employees: 6514 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Methyl ethyl ketone peroxide, 3508
NTP Toxicity studies, RPT# TOX-18, October 1997
*** END OF RECORD ***