*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EL8577650
CHEMICAL NAME           : 1-Butanone,
                          4-(4-(4-fluorobenzoyl)-1-piperidinyl)-1-(4-fluorophen
                          yl)-
CAS REGISTRY NUMBER     : 24678-13-5
BEILSTEIN REFERENCE NO. : 1554429
REFERENCE               : 5-21-08-00146 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H23-F2-N-O2
MOLECULAR WEIGHT        : 371.46
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AHR-2277
   * 4-(4-(4-Fluorobenzoyl)-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone
   * 4'-Fluoro-4-(4-(p-fluorobenzoyl)piperidino)butyrophenone
   * Lenperona
   * Lenperone
   * Lenperonum (Latin)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90100 ug/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
REFERENCE :
   DECRDP Drugs under Experimental and Clinical Research.  (Bioscience
   Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland)  V.1-    1977-
   Volume(issue)/page/year: 4,1,1978
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1270 mg/kg/22W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1709,1980
 
                            *** END OF RECORD ***