*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EK7879100
CHEMICAL NAME           : Butanoic acid,
                          2-hydroxy-2-(1-methoxyethyl)-3-methyl-,
                          (2,3,5,7a-tetrahydro-1-hydroxy-1H-
                          pyrrolizin-7-yl)methyl ester, 4-oxide, hydrochloride,
                          (1S-(1-alpha,7(2R*,3S*)7a-alpha))-
LAST UPDATED            : 199309
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H27-N-O6.Cl-H
MOLECULAR WEIGHT        : 365.90
COMPOUND DESCRIPTOR     : Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Heliotrine oxide hydrochloride
   * Heliotrine N-oxide hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Vascular - other changes
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - hemorrhage
REFERENCE :
   FRBGAT Frontiers of Biology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1966- Volume(issue)/page/year:
   9,142,1968

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***