*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EK7791200
CHEMICAL NAME           : Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-,
                          (2,3,5,7a-tetrahydro-1-hydroxy-1H-
                          pyrrolizin-7-yl)methyl ester, N-oxide,
                          (1R-(1-apha,7(2R*,3S),7-a lpha,beta))-
CAS REGISTRY NUMBER     : 41708-76-3
BEILSTEIN REFERENCE NO. : 5764712
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C15-H25-N-O6
MOLECULAR WEIGHT        : 315.41
SYNONYMS/TRADE NAMES :
   * INDI
   * Indicine N-oxide
   * NSC-132,319
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1917 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3733 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-161694
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GVRAAS Government Reports Announcements. (U.S.)  (Washington, D.C.) V.71(6)
   -75(6), 1971-75. Merged with Government Reports Index (US) to form
   Government Reports Announcement Index (U.S.)  Volume(issue)/page/year:
   74(9),60,1974
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 24 gm/kg/4W-I
TOXIC EFFECTS :
   Blood - macrocytosis
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   101,271,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1350 mg/kg/9D-I
TOXIC EFFECTS :
   Blood - macrocytosis
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   101,271,1989
 
                            *** END OF RECORD ***