*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EK7745000
CHEMICAL NAME           : Butanoic acid, 4-(4-chloro-2-methylphenoxy)-, ethyl
                          ester
CAS REGISTRY NUMBER     : 10443-70-6
LAST UPDATED            : 199612
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C13-H17-Cl-O3
MOLECULAR WEIGHT        : 256.75
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Butyric acid, 4-((4-chloro-o-tolyl)oxy)-, ethyl ester
   * Ethyl 4-(2-methyl-4-chlorophenoxy)butylate
   * MCPBE
   * MCPB ethyl
   * MCPB ethyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1420 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3000 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 870 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3910 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 525 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 31200 mg/kg/13W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - changes in spleen weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 131 gm/kg/2Y-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg/6W-I
TOXIC EFFECTS :
   Behavioral - tremor
   Gastrointestinal - hypermotility, diarrhea
   Liver - other changes
REFERENCE :
   AMBNAS Acta Medica et Biologica (Niigata).  (Niigata Univ. School of
   Medicine, 1 Asahi-machi-dori, Niigata 951, Japan)  V.1-    1953-
   Volume(issue)/page/year: 38,97,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg/12W-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AMBNAS Acta Medica et Biologica (Niigata).  (Niigata Univ. School of
   Medicine, 1 Asahi-machi-dori, Niigata 951, Japan)  V.1-    1953-
   Volume(issue)/page/year: 38,97,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5475 mg/kg/2Y-C
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 17,S39,1992
 
                            *** END OF RECORD ***