*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EK6110000
CHEMICAL NAME           : Butane, 1,2,3,4-tetrachloro-
CAS REGISTRY NUMBER     : 3405-32-1
LAST UPDATED            : 199509
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C4-H6-Cl4
MOLECULAR WEIGHT        : 195.90
WISWESSER LINE NOTATION : G1YGYG1G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 1,2,3,4-Tetrachlorobutane
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 46(1),92,1981
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1160 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny.  Journal of
   Experimental and Clinical Medicine.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.2-    1962-  Volume(issue)/page/year: 26,23,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 111 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny.  Journal of
   Experimental and Clinical Medicine.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.2-    1962-  Volume(issue)/page/year: 26,23,1986
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 910 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny.  Journal of
   Experimental and Clinical Medicine.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.2-    1962-  Volume(issue)/page/year: 26,23,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29900 ug/m3/4H/17W-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - changes in spleen
REFERENCE :
   VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI).
   All-Union Institute of Scientific and Technical Information.  (Moscow, USSR)
    Use information broker to obtain publications. Volume(issue)/page/year:
   #1411-84
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 9100 ug/m3/4H
REFERENCE :
   ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny.  Journal of
   Experimental and Clinical Medicine.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.2-    1962-  Volume(issue)/page/year: 24,237,1984
 
                            *** END OF RECORD ***