*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EC1450000
CHEMICAL NAME           : Biurea, 1,6-dimethyl-1,6-dinitroso-
CAS REGISTRY NUMBER     : 3844-60-8
BEILSTEIN REFERENCE NO. : 2125382
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C4-H8-N6-O4
MOLECULAR WEIGHT        : 204.18
WISWESSER LINE NOTATION : ONN1&VMMVN1&NO
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * 1,6-Dimethyl-1,6-dinitrosobiurea
   * 1,2-Hydrazinedicarboxamide, N,N'-dimethyl-N,N'-dinitroso-
   * Hydrazodicarbonsaeureabis(methylnitrosamid)
   * Hydrazodicarboxylic acid bis(methylnitrosamide)
   * Hydroazodicarboxybis(methylnitrosamide)
   * NSC 409425
   * SRI 1666
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   69,103,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56570 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 420 mg/kg/28W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   69,103,1967
 
                            *** END OF RECORD ***