*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EJ3500970
CHEMICAL NAME           : Butanamide,
                          4-(((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyle
                          ne)amino)-
CAS REGISTRY NUMBER     : 62666-20-0
BEILSTEIN REFERENCE NO. : 2339306
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C17-H16-Cl-F-N2-O2
MOLECULAR WEIGHT        : 334.80
WISWESSER LINE NOTATION : ZV3NUYR DG&R BQ EF
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
SYNONYMS/TRADE NAMES :
   * Butyramide,  
   4-(alpha-(p-chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino)-
   * 4-(alpha-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino)butyramide
   * 4-(((4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene)amino)butanamide
   * Halogabide
   * Progabide
   * SL 76-002
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches
   Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036)  V.1-    1983-  Volume(issue)/page/year: 3,203,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches
   Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036)  V.1-    1983-  Volume(issue)/page/year: 3,203,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4094992
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 655 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - adrenal cortex tumors
REFERENCE :
   LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches
   Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036)  V.1-    1983-  Volume(issue)/page/year: 3,203,1985
 
                            *** END OF RECORD ***