*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EI9799000
CHEMICAL NAME           : 1,3-Butadiene, dichloro-
CAS REGISTRY NUMBER     : 28577-62-0
LAST UPDATED            : 198910
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C4-H4-Cl2
MOLECULAR WEIGHT        : 122.98
WISWESSER LINE NOTATION : G1U2U1G
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * DCBD
   * Dichlorobutadiene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14 mg/m3/4H
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 41(8),96,1976
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14 mg/m3/4H
SEX/DURATION            : male 16 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 41(8),96,1976
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14 mg/m3/4H
SEX/DURATION            : male 4 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 41(8),96,1976
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 51 mg/m3/24H
SEX/DURATION            : female 1-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny.  Journal of
   Experimental and Clinical Medicine.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.2-    1962-  Volume(issue)/page/year: 17,16,1977
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 51 mg/m3/24H
SEX/DURATION            : female 1-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny.  Journal of
   Experimental and Clinical Medicine.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.2-    1962-  Volume(issue)/page/year: 17,16,1977
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 51 mg/m3/24H
SEX/DURATION            : female 1-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny.  Journal of
   Experimental and Clinical Medicine.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.2-    1962-  Volume(issue)/page/year: 17,16,1977
 
                            *** END OF RECORD ***