*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EI3175800
CHEMICAL NAME           : 5-beta-Bufa-20,22-dienolide,
                          3-beta,5,14-trihydroxy-19-oxo-
CAS REGISTRY NUMBER     : 465-90-7
BEILSTEIN REFERENCE NO. : 0056259
REFERENCE               : 5-18-05-00180 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C24-H32-O6
MOLECULAR WEIGHT        : 416.56
WISWESSER LINE NOTATION : L E5 B666TJ AVH E1 IQ MQ OQ F- ET6OVJ
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Bufotalidin
   * Gellebrigenin
   * Hellebrigenin
   * 19-Oxo-3-beta,5,14-trihydroxy-5-beta-bufa-20,22-dienolide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 77 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHUZBI Pharmazie in Unserer Zeit.  (VCH Pub., Inc., 303 N.W. 12th Ave.,
   Deerfield Beach, FL 33441) V.1-    1972-  Volume(issue)/page/year:
   13,129,1984
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1345 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 252,314,1966
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 514 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 24,179,1974

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster,
   Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963  Volume(issue)/page/year:
   -,191,1963

 
                            *** END OF RECORD ***