*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EI2990000
CHEMICAL NAME           : 5-beta-Bufa-20,22-dienolide,
                          14,15-beta-epoxy-3-beta,5,16-beta-trihydroxy-
CAS REGISTRY NUMBER     : 4099-30-3
OTHER CAS REGISTRY NOS. : 61854-81-7
LAST UPDATED            : 199712
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C24-H32-O6
MOLECULAR WEIGHT        : 416.56
WISWESSER LINE NOTATION : T E6 B6653 1A R AX RO QHTTTT&J EQ GQ J1 N1 PQ O-
                          ET6OVJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bufa-20,22-dienolide, 14,15-epoxy-3,5,16-trihydroxy-,  
   (3-beta,5-beta,15-beta,16-beta)-
   * Desacetylcinobufotalin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle contraction or spasticity
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 24,1714,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 1070 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMPCAS Journal of Medicinal and Pharmaceutical Chemistry.  (Washington, DC)
   V.1-5, 1959-62.  For publisher information, see JMCMAR.
   Volume(issue)/page/year: 3,111,1961
 
                            *** END OF RECORD ***