*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EI2958000
CHEMICAL NAME : 5-beta-Bufa-20,22-dienolide,
3-beta-((6-deoxy-4-O-beta-D-glucopyranosyl-alpha-L-
mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-
CAS REGISTRY NUMBER : 13289-18-4
OTHER CAS REGISTRY NOS. : 12626-45-8
BEILSTEIN REFERENCE NO. : 0077007
REFERENCE : 4-18-00-03181 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C36-H52-O15
MOLECULAR WEIGHT : 724.88
WISWESSER LINE NOTATION : L E5 B666TJ AVH E1 IQ MQ F- ET6OVJ& OO- BT6OTJ CQ DQ
F1 EO- BT6OTJ CQ DQ EQ F1Q
COMPOUND DESCRIPTOR : Natural Product
SYNONYMS/TRADE NAMES :
* Hellebrigenin-gluco-rhamnosid
* Hellebrigenin glucorhamnoside
* Hellebrin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 155,165,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 155,165,1965
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FARMA8 Farmacognosia. (Madrid, Spain) V.1-27, 1942-62. Discontinued.
Volume(issue)/page/year: 13,375,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 104 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 99,395,1950
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 616 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 252,314,1966
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 320 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb,
Yugoslavia) V.1-41, 1951-1991. Volume(issue)/page/year: 24,179,1974
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 166 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb,
Yugoslavia) V.1-41, 1951-1991. Volume(issue)/page/year: 24,179,1974
*** REVIEWS ***
TOXICOLOGY REVIEW
85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster,
Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year:
-,191,1963
*** END OF RECORD ***