*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DW4000000
CHEMICAL NAME           : (4,4'-Bi-3-pyrazoline)-5,5'-dione,
                          1,1'-diphenyl-2,2',3,3'-tetramethyl-
CAS REGISTRY NUMBER     : 517-83-9
BEILSTEIN REFERENCE NO. : 0351034
REFERENCE               : 4-26-00-02474 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H22-N4-O2
MOLECULAR WEIGHT        : 374.48
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Forbisen
   * SN 475
   * 2,2',3,3'-Tetramethyl-1,1'-diphenyl(4,4'-bi-3-pyrazoline)-5,5'-dione
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,233,1946
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 15 gm/kg/22W-I
TOXIC EFFECTS :
   Behavioral - ataxia
   Blood - normocytic anemia
   Related to Chronic Data - death
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,233,1946
 
                            *** END OF RECORD ***