*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DW1080000
CHEMICAL NAME           : (3,4'-Bipiperidine)-2,6-dione,
                          3-phenyl-1'-(phenylmethyl)-, hydrochloride, (S)-
CAS REGISTRY NUMBER     : 21888-96-0
LAST UPDATED            : 199012
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H26-N2-O2.Cl-H
MOLECULAR WEIGHT        : 398.97
WISWESSER LINE NOTATION : T6VMVTJ DR& D- DT6NTJ D1R &GH -S
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (+)-1-Benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)piperidine hydrochloride
   * (+)-2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide hydrochloride
   * (+)-3-(1-Benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione hydrochloride
   * Dexbenzetimide hydrochloride
   * Dexetimide hydrochloride
   * Dextrobenzetimide hydrochloride
   * (S)-3-Phenyl-1'-(phenylmethyl)-(3,4'-bipiperidine)-2,6-dione  
   hydrochloride
   * R 16470
   * Tremblex
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,219,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,1365,1971
 
                            *** END OF RECORD ***