*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DV8660000
CHEMICAL NAME           : 1,1'-Biphenyl, 2,2',5,5'-tetrachloro-
CAS REGISTRY NUMBER     : 35693-99-3
BEILSTEIN REFERENCE NO. : 2053828
REFERENCE               : 4-05-00-01818 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C12-H6-Cl4
MOLECULAR WEIGHT        : 291.98
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * PCB 52
   * 2,2',5,5'-TCB
   * 2,2',5,5'-Tetrachlorobiphenyl
   * 2,5,2',5'-Tetrachlorobiphenyl
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg/3D-I
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other esterases
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other Enzymes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   33,94,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg/4D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   100,315,1989
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 20 mg/L
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 24,313,1979

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***