*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DU3120000
CHEMICAL NAME           : (8,8'-Bi-1H-naphtho(2,3-c)pyran)-3,3'-diacetic acid,
                          3,3',4,4'-tetrahydro-
                          9,9',10,10'-tetrahydroxy-7,7'-dimethoxy-1,1'-dioxo-,
                          dimethyl ester
CAS REGISTRY NUMBER     : 35483-50-2
LAST UPDATED            : 199304
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C30-H26-O6
MOLECULAR WEIGHT        : 482.56
WISWESSER LINE NOTATION : T C666 EOT&&J F1VQ M- MT C666 EOT&&J F1VQ
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * SC 28762
   * Viriditoxin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 5,408,1981
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3500 ug/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 14,175,1976

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***