*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DU3100000
CHEMICAL NAME : (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde,
1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-
3,3'-dimethyl-
CAS REGISTRY NUMBER : 303-45-7
BEILSTEIN REFERENCE NO. : 1917878
REFERENCE : 4-08-00-03754 (Beilstein Handbook Reference)
LAST UPDATED : 199803
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C30-H30-O8
MOLECULAR WEIGHT : 518.60
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Human
Natural Product
SYNONYMS/TRADE NAMES :
* 2,2'-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene)
* 8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2,2'-bisnaphthalene
* Gossypol
* Tash 1
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL)
V.24-56, 1947-79. Volume(issue)/page/year: 37,40,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 550 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL)
V.24-56, 1947-79. Volume(issue)/page/year: 40,571,1963
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE : 17 mg/kg
SEX/DURATION : male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
CMJODS Chinese Medical Journal (Beijing, English Edition). (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 4,417,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 700 mg/kg
SEX/DURATION : male 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
CDESDK Contraceptive Delivery Systems. (Kluwer Academic Pub. Group,
Distribution Centre, POB 322, 3300 AH Dordrecht, Netherlands) V.1- 1980-
Volume(issue)/page/year: 3,#278,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1050 mg/kg
SEX/DURATION : male 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and
Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku,
Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 26,393,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE : 4500 mg/kg
SEX/DURATION : male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year:
13,199,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 525 mg/kg
SEX/DURATION : male 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 37,311,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 700 mg/kg
SEX/DURATION : male 70 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 37,311,1982
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 10 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,35,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - hamster Lymphocyte
DOSE/DURATION : 50 mg/L/48H
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 19,53,1983
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human - man Lymphocyte
DOSE/DURATION : 9 ug/plate
REFERENCE :
CPHPA5 Jiepou Xuebao. Journal of Anatomy. (China International Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-9, 1953-66; V.10-
1979- Volume(issue)/page/year: 12,293,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human - man Lymphocyte
DOSE/DURATION : 1 ug/plate
REFERENCE :
CPHPA5 Jiepou Xuebao. Journal of Anatomy. (China International Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-9, 1953-66; V.10-
1979- Volume(issue)/page/year: 12,293,1981
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 10 mg/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 19,53,1983
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 50 mg/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 19,53,1983
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 10 mg/L/48H
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 19,53,1983
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-rat; Sperm
morphology-human
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-rabbit
*** END OF RECORD ***