*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DU3000000
CHEMICAL NAME : (delta(sup 2,2')-Biindoline)-5,5'-disulfonic acid,
3,3'-dioxo-, disodium salt
CAS REGISTRY NUMBER : 860-22-0
LAST UPDATED : 199709
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C16-H8-N2-O8-S2.2Na
MOLECULAR WEIGHT : 466.36
WISWESSER LINE NOTATION : T56 BMYVJ GSWO CU- CT56 BMYVJ GSWO &-NA- 2
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Acid Blue W
* Acid Leather Blue IC
* A.F. Blue No. 2
* Airedale Blue IN
* Amacid Brilliant Blue
* Aniline Carmine powder
* Atul Indigo Carmine
* 1311 Blue
* 12070 Blue
* Bucacid indigotine B
* Canacert Indigo Carmine
* Carmine Blue (biological stain)
* C.I. 73015
* C.I. 75781
* C.I. Acid Blue 74
* C.I. Food Blue 1
* C.I. Food Blue 1, disodium salt
* Cilefa Blue R
* C.I. Natural Blue 2
* Disodium indigo-5,5-disulfonate
* Disodium salt of 1-indigotin-S,S'-disulphonic acid
* Dolkwal Indigo Carmine
* E 132
* Edicol Supra Blue X
* FD and C Blue No. 2
* Food Blue 2
* Grape Blue A Geigy
* HD Indigo Carmine
* HD Indigo Carmine Supra
* Hexacert Blue No. 2
* Hexacol Indigo Carmine Supra
* Indigo Carmine
* Indigo Carmine A
* Indigo Carmine AC
* Indigo Carmine (biological stain)
* Indigo Carmine BP
* Indigo Carmine Conc. FQ
* Indigo Carmine disodium salt
* Indigo Carmine powder
* Indigo Carmine X
* Indigo disulfonate (biological stain)
* Indigo extract
* Indigo-karmin
* Indigotin I
* 5,5'-Indigotindisulfonic acid
* Indigotin-5,5'-disulfonic acid disodium salt
* Indigotine
* Indigotine B
* Indigotine Blue LZ
* Indigotine conc. powder
* Indigotine disodium salt
* Indigotine Extra Pure A
* Indigotine I
* Indigotine Lake
* Indigotine N
* Indocarmine F
* Intense Blue
* L-Blau 2
* Maple Indigo Carmine
* Mitsui Indigo Carmine
* Modr Kysela 74
* Modr Pigment 63
* Modr Potravinarska 1
* Murabba
* Sachsischblau
* San-ei Indigo Carmine
* Schultz Nr. 1309
* Sodium indigotindisulfonate
* Sodium 5,5'-indigotidisulfonate
* Soluble indigo
* Sumitomo Wool Blue SBC
* Usacert Blue No. 2
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCPHA4 Scientia Pharmaceutica. (Oesterreichische
Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
V.1- 1930- Volume(issue)/page/year: 47,39,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,83,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCPHA4 Scientia Pharmaceutica. (Oesterreichische
Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
V.1- 1930- Volume(issue)/page/year: 47,39,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 405 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCPHA4 Scientia Pharmaceutica. (Oesterreichische
Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
V.1- 1930- Volume(issue)/page/year: 47,39,1979
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
8,29,1966
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 5400 mg/kg/90D (Continuous)
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 54,25,1988
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 60 mg/kg/30D (Continuous)
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
30,315,1986
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 25 mg/kg
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
52,33,1990
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 12 gm/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
22,623,1984
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84752
No. of Facilities: 314 (estimated)
No. of Industries: 5
No. of Occupations: 6
No. of Employees: 1736 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84752
No. of Facilities: 393 (estimated)
No. of Industries: 7
No. of Occupations: 28
No. of Employees: 9691 (estimated)
No. of Female Employees: 3035 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***