*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DU2077000
CHEMICAL NAME           : Biguanide, 1-(p-((p-nitrophenyl)thio)phenyl)-
CAS REGISTRY NUMBER     : 20567-00-4
BEILSTEIN REFERENCE NO. : 2176302
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C14-H14-N6-O2-S
MOLECULAR WEIGHT        : 330.40
WISWESSER LINE NOTATION : WNR DSR DMYUM&MYZUM
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Imidodicarbonimidic diamide, N-(4-((4-nitrophenyl)thio)phenyl)-
   * 1-(p-((p-Nitrophenyl)thio)phenyl)biguanide
   * N-(4-((4-Nitrophenyl)thio)phenyl)imidodicarbonimidic diamide
   * T-1212
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   38,425,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 875 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPFAR Acta Poloniae Pharmaceutica (English Translation).  Translation of
   APPHAX.  (Warsaw, Poland) V.20-29, 1963-72.  Discontinued.
   Volume(issue)/page/year: 26,487,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPFAR Acta Poloniae Pharmaceutica (English Translation).  Translation of
   APPHAX.  (Warsaw, Poland) V.20-29, 1963-72.  Discontinued.
   Volume(issue)/page/year: 26,487,1969
 
                            *** END OF RECORD ***