*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DU1925000
CHEMICAL NAME : Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-
CAS REGISTRY NUMBER : 55-56-1
BEILSTEIN REFERENCE NO. : 2826432
REFERENCE : 4-12-00-01201 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C22-H30-Cl2-N10
MOLECULAR WEIGHT : 505.52
WISWESSER LINE NOTATION : GR DMYUM&MYUM&M6MYUM&MYUM&MR DG
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane
* 1,6-Bis(p-chlorophenyldiguanido)hexane
* Chlorhexidin
* Chlorhexidine
* 1,6-Di(4'-chlorophenyldiguanido)hexane
* Fimeil
* Hexadol
* 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)
* Nolvasan
* Rotersept
* Soretol
* Sterilon
* 2,4,11,13-Tetraazatetradecanediimidamide,
N,N''-bis(4-chlorophenyl)-3,12-diimino-
* Tubulicid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human
DOSE/DURATION : 1500 ug/3D (Intermittent)
REACTION SEVERITY : Mild
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9200 uL/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 6,2599,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VTYMAC VM/SAC, Veterinary Medicine and Small Animal Clinician. (Veterinary
Medicine Publishing Co., 690 S. 4th St., POB 13265, Edwardsville, KS 66113)
V.59- 1964- Volume(issue)/page/year: 72,1330,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JCPEDZ Journal of Clinical Periodontology. (Munksgaard International
Publishers, POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1974-
Volume(issue)/page/year: 4(5),66,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RMISDU International Congress and Symposium Series - Royal Society of
Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E.
60th St., New York, NY 10022) No.1- 1978- Volume(issue)/page/year:
23,45,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2515 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
RMISDU International Congress and Symposium Series - Royal Society of
Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E.
60th St., New York, NY 10022) No.1- 1978- Volume(issue)/page/year:
23,45,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 44 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VTYMAC VM/SAC, Veterinary Medicine and Small Animal Clinician. (Veterinary
Medicine Publishing Co., 690 S. 4th St., POB 13265, Edwardsville, KS 66113)
V.59- 1964- Volume(issue)/page/year: 72,1330,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 632 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCPEDZ Journal of Clinical Periodontology. (Munksgaard International
Publishers, POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1974-
Volume(issue)/page/year: 4(5),66,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 24 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCPEDZ Journal of Clinical Periodontology. (Munksgaard International
Publishers, POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1974-
Volume(issue)/page/year: 4(5),66,1977
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VTYMAC VM/SAC, Veterinary Medicine and Small Animal Clinician. (Veterinary
Medicine Publishing Co., 690 S. 4th St., POB 13265, Edwardsville, KS 66113)
V.59- 1964- Volume(issue)/page/year: 72,1330,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 150 uL/kg/30D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Biochemical - Metabolism (Intermediary) - lipids including transport
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 6,2599,1978
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1680 mg/kg
SEX/DURATION : female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64;
V.18-19, 1968-69. For publisher information, see JNMDBO.
Volume(issue)/page/year: 10,361,1964
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 14300 pmol/plate
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
28,249,1979
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 7 umol/disc
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
28,249,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84812
No. of Facilities: 8 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 32 (estimated)
No. of Female Employees: 32 (estimated)
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***