*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DU1788500
CHEMICAL NAME           : Biguanide, 1,1-dibutyl-, monohydrochloride
CAS REGISTRY NUMBER     : 101491-39-8
LAST UPDATED            : 199412
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C10-H23-N5.Cl-H
MOLECULAR WEIGHT        : 249.84
WISWESSER LINE NOTATION : MUYZMYUM&N4&4 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1,1-Dibutylbiguanide hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,314,1962
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6000 mg/kg/30D-I
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Liver - other changes
   Liver - multiple effects
REFERENCE :
   CYTPDT Zhongyao Tongbao.  Bulletin of Chinese Materia Medica.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
   V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3
   Volume(issue)/page/year: 13,306,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 36400 mg/kg/26W-I
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Liver - other changes
   Liver - multiple effects
REFERENCE :
   CYTPDT Zhongyao Tongbao.  Bulletin of Chinese Materia Medica.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
   V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3
   Volume(issue)/page/year: 13,306,1988
 
                            *** END OF RECORD ***