*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DT7350000
CHEMICAL NAME : (Bicyclohexyl)-1-carboxylic acid,
2-(diethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER : 67-92-5
LAST UPDATED : 199701
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C19-H35-N-O2.Cl-H
MOLECULAR WEIGHT : 346.01
WISWESSER LINE NOTATION : L6TJ A- AL6TJ AVO2N2&2 &GH
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Atumin
* Bentomine
* Bentyl hydrochloride
* Bentylol hydrochloride
* (1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester,
hydrochloride
* Bis(cyclohexyl)carboxylic acid diethylaminoethyl ester hydrochloride
* Cloridrato dell'estere beta-dietil aminoetilico dell'acido
cicloesil-1-cicloesancarbossilico
* 1-Cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester
hydrochlorid
* Dicyclomine hydrochloride
* Dicycloverin hydrochloride
* Diethylaminocarbethoxybicyclohexyl hydrochloride
* 2-(Diethylamino)ethyl (bicyclohexyl)-1-carboxylate hydrochloride
* beta-Diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate hydrochloride
* beta-Diethylaminoethyl-1-cyclohexylhexahydrobenzoate hydrochloride
* Diocyl hydrochloride
* Di-syntramine
* Dyspas
* Kolantyl hydrochloride
* Mamiesan
* Merbentyl
* Oxityl-P
* Procyclomin
* Wyovin hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - infant
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
288,901,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1290 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 8,1954,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 625 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 39,305,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FSTEAI Farmaco. Scienza e Tecnica. (Pavia, Italy) V.1-7, 1946-52. For
publisher information, see FRPSAX. Volume(issue)/page/year: 7,448,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 31500 ug/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
spasmolytic)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 11,1119,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - hematuria
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 39,305,1950
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26 gm/kg/30D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Blood - normocytic anemia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 8,1954,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 39 gm/kg/13W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in other cell count (unspecified)
Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 8,1954,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 31200 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 8,1954,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84599
No. of Facilities: 805 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 805 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84599
No. of Facilities: 188 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 9355 (estimated)
No. of Female Employees: 8012 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***