*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DP1584000
CHEMICAL NAME           : Benzylamine, N,N-bis(2-chloroethyl)-p-fluoro-,
                          hydrochloride
CAS REGISTRY NUMBER     : 1645-07-4
LAST UPDATED            : 199603
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C11-H14-Cl2-F-N.Cl-H
MOLECULAR WEIGHT        : 286.62
WISWESSER LINE NOTATION : G2N2G1R DF &GH
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * N,N-Bis(2-chloroethyl)-p-fluorobenzylamine hydrochloride
   * p-Fluoro-di-(2-chloroethyl)-benzylamine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 35 mg/kg/5W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 27,1057,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10500 ug/kg/5W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 27,1057,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   SOGEBZ Soviet Genetics.  English translation of GNKAA5.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.2-    1966- Volume(issue)/page/year:
   6,220,1970
 
                            *** END OF RECORD ***