*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DP1230000
CHEMICAL NAME           : Benzyl alcohol, alpha-((2-pyrimidinylamino)methyl)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 2441-88-5
LAST UPDATED            : 199503
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C12-H13-N3-O.Cl-H
MOLECULAR WEIGHT        : 251.74
WISWESSER LINE NOTATION : T6N CNJ BM1YQR &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzenemethanol, alpha-((2-pyrimidinylamino)methyl)-, monohydrochloride
   * Fenyripol hydrochloride
   * 2-(beta-Hydroxy-beta-phenethylamino)-pyrimidine hydrochloride
   * 2-(beta-Hydroxy-beta-phenyl-ethyl-amino)-pyrimidine chlorhydrate
   * IN 836
   * alpha-((2-Pyrimidinylamino)methyl)benzyl alcohol hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 235 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 141,83,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 141,83,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AAREAV Anesthesie, Analgesie, Reanimation.  (Paris, France)  V.14-38,
   1957-81.  Volume(issue)/page/year: 22,87,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AAREAV Anesthesie, Analgesie, Reanimation.  (Paris, France)  V.14-38,
   1957-81.  Volume(issue)/page/year: 22,87,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 141,83,1963
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AAREAV Anesthesie, Analgesie, Reanimation.  (Paris, France)  V.14-38,
   1957-81.  Volume(issue)/page/year: 22,87,1965
 
                            *** END OF RECORD ***