*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DO3500000
CHEMICAL NAME : Benzyl alcohol,
3,4-dihydroxy-alpha-((methylamino)methyl)-, (-)-,
tartrate (1:1), (+)-
CAS REGISTRY NUMBER : 51-42-3
LAST UPDATED : 199706
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C9-H13-N-O3.C4-H6-O6
MOLECULAR WEIGHT : 333.33
WISWESSER LINE NOTATION : QR BQ DYQ1M1 &QVYQYQVQ -L -D
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Adrenalin bitartrate
* Adrenaline acid tartrate
* (-)-Adrenaline acid tartrate
* Adrenaline bitartrate
* l-Adrenaline bitartrate
* (-)-Adrenaline bitartrate
* l-Adrenaline d-bitartrate
* Adrenaline hydrogen tartrate
* (-)-Adrenaline hydrogen tartrate
* l-Adrenaline hydrogen tartrate
* Adrenaline tartrate
* (-)-Adrenaline tartrate
* l-Adrenaline tartrate
* L-Adrenaline tartrate
* (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol (+)-tartrate
(1:1) salt
* Epinephrine bitartrate
* Epinephrine d-bitartrate
* (-)-Epinephrine bitartrate
* l-Epinephrine bitartrate
* L-Epinephrine bitartrate
* l-Epinephrine d-bitartrate
* Epinephrine hydrogen tartrate
* Epinephrine tartrate
* l-Epinephrine tartrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,122,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 82 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 137,155,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,49,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7800 ug/kg
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,43,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 11100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
55,73,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1780 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 81,269,1944
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Cardiac - other changes
Gastrointestinal - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 76 mg/kg/42D-I
TOXIC EFFECTS :
Cardiac - other changes
Liver - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
25,315,1973
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 2400 ug/kg
SEX/DURATION : male 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 22,375,1970
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,3514,1983
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82895
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 504 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82895
No. of Facilities: 34 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 1721 (estimated)
No. of Female Employees: 1639 (estimated)
*** END OF RECORD ***