*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DN6750000
CHEMICAL NAME           : Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-,
                          (-)-, tartrate (1:1)
CAS REGISTRY NUMBER     : 51-40-1
LAST UPDATED            : 199504
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C8-H11-N-O3.C4-H6-O6
MOLECULAR WEIGHT        : 319.30
WISWESSER LINE NOTATION : Z1YQR CQ DQ &OVYQYQVO
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * l-Arterenol bitartrate
   * Levarterenol bitartrate
   * Noradrenaline acid tartrate
   * (-)-Noradrenaline acid tartrate
   * Noradrenaline bitartrate
   * (-)-Noradrenaline bitartrate
   * l-Noradrenaline bitartrate
   * L-Noradrenaline bitartrate
   * (-)-Noradrenaline bitartrate monohydrate
   * Noradrenaline hydrogen tartrate
   * Noradrenaline tartrate
   * Noradrenaline, tartrate (1:1)
   * (-)-Noradrenaline tartrate
   * l-Noradrenaline tartrate
   * (-)-Norepinephrine bitartrate
   * l-Norepinephrine bitartrate
   * Norepinephrine tartrate
   * (-)-Norepinephrine tartrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3987 ug/kg
TOXIC EFFECTS :
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 95,155,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 210 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 7,627,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae.  (Warsaw, Poland)
   V.18-24, 1966-72.  For publisher information, see PJPPAA.
   Volume(issue)/page/year: 23,435,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1025 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   9,289,1970
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,523,1988

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5302
       No. of Facilities: 7 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 628 (estimated)
       No. of Female Employees: 314 (estimated)

 
                            *** END OF RECORD ***