*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DM4210000
CHEMICAL NAME           : 1H-2,5-Benzoxazocine,
                          3,4,5,6,7-tetrahydro-5-methyl-1-phenyl-
CAS REGISTRY NUMBER     : 13669-70-0
LAST UPDATED            : 199703
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C17-H19-N-O
MOLECULAR WEIGHT        : 253.37
WISWESSER LINE NOTATION : T68 HN KO&TJ H1 LR
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Fenazoxine
   * Nefopam
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Cardiac - change in rate
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   283,1508,1981
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - excitement
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   283,1508,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4198424
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
   DDEVD6 Drug Development and Evaluation.  (Gustav Fischer Verlag, Postfach
   720143, D-7000 Stuttgart 70, Fed. Rep. Ger.)  V.1-    1977-
   Volume(issue)/page/year: 3,10,1979
 
                            *** END OF RECORD ***