*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DK9800000
CHEMICAL NAME           : 4H-1,2,4-Benzothiadiazine-7-sulfonamide,
                          6-(trifluoromethyl)-, 1,1-dioxide
CAS REGISTRY NUMBER     : 148-56-1
LAST UPDATED            : 199601
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C8-H6-F3-N3-O4-S2
MOLECULAR WEIGHT        : 329.29
WISWESSER LINE NOTATION : T66 BSWM ENJ HXFFF ISZW
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ademil
   * Ademol
   * Fludemil
   * Flumethiazide
   * Flumetiazid
   * Routrax
   * 6-(Trifluoromethyl)-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide
   * 6-(Trifluoromethyl)-1,4,2-benzothiadiazine-7-sulfonamido 1,1-dioxide
   * 6-Trifluoromethyl-7-sulfamoyl-4H-1,4,2-benzothiadiazine 1,1-dioxide
   * 6-Trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
   * Trifluoromethylthiazide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >8 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1760 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 910 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - ataxia
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 128,405,1960
 
                            *** END OF RECORD ***