*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DK9625000
CHEMICAL NAME           : 2H-1,2,4-Benzothiadiazine-7-sulfonamide,
                          3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide
CAS REGISTRY NUMBER     : 135-09-1
BEILSTEIN REFERENCE NO. : 0342692
REFERENCE               : 4-27-00-08035 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H8-F3-N3-O4-S2
MOLECULAR WEIGHT        : 331.31
WISWESSER LINE NOTATION : T66 BSWM EM DHJ HXFFF ISZW
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bristab
   * Bristurin
   * Di-ademil
   * Dihydroflumethiazide
   * 3,4-Dihydro-7-sulfamyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine  
   1,1-dioxide
   * 3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazine-7-sulfonamide  
   1,1-dioxide
   * 3,4-Dihydro-6-trifluoromethyl-7-sulfamoylbenzo-1,2,4-thiadiazine  
   1,1-dioxide
   * Diucardin
   * Elodrin
   * Elodrine
   * Finuret
   * Flutizide
   * Glomerulin
   * Hidroalogen
   * Hidroflumetiazid
   * Hydol
   * Hydrenox
   * Hydroflumethiazide
   * Leodrine
   * Metflorylthiazidine
   * Methforylthiazidine
   * NaClex
   * Olmagran
   * Rodiuran
   * Rontyl
   * Saluron
   * Sisuril
   * Spandiuril
   * 7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine  
   1,1-dioxide
   * 6-Trifluoromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine  
   1,1-dioxide
   * Trifluoromethylhydrothiazide
   *   6-Trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-diox
     ide
   * Vergonil
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,629,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6280 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1182 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   FMXXAJ French Medicament Patent Document.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Discontinued.
   Volume(issue)/page/year: #80M
 
                            *** END OF RECORD ***