*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AH3749000
CHEMICAL NAME           : Acetic acid, 2-(ethylbutoxy)diphenyl-,
                          2-(dimethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER     : 3321-06-0
LAST UPDATED            : 199712
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C24-H33-N-O3.Cl-H
MOLECULAR WEIGHT        : 420.04
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * O-(2-Aethylbutoxy)-benzilsaeure-2-dimethylaminoaethyl ester hydrochlorid
   * Benzeneacetic acid, alpha-(2-ethylbutoxy)-alpha-phenyl-,  
   2-(dimethylamino)ethyl ester, HCl
   * Denaverine hydrochloride
   * Spasmalgan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 112 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   109,115,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4425 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   109,115,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   109,115,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 370 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   109,115,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 138 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   109,115,1970
 
                            *** END OF RECORD ***