*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AH2975000
CHEMICAL NAME           : Acetic acid, diphenyl-, 1-ethyl-3-piperidyl ester,
                          hydrochloride
CAS REGISTRY NUMBER     : 129-77-1
LAST UPDATED            : 199603
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C21-H25-N-O2.Cl-H
MOLECULAR WEIGHT        : 359.93
WISWESSER LINE NOTATION : T6NTJ A2 COVYR&R &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AN 1087
   * Benzeneacetic acid, alpha-phenyl-, 1-ethyl-3-piperidinyl ester,  
   hydrochloride
   * Benzeneacetic acid, alpha-phenyl-, 1-ethyl-3-piperidyl ester,  
   hydrochloride
   * Dactil hydrochloride
   * Diphenylacetic acid, 1-ethyl-3-piperidyl ester hydrochloride
   * N-Ethyl-3-piperidyl diphenylacetate hydrochloride
   * 1-Ethyl-3-piperidyl diphenyl-acetate hydrochloride
   * 3-Piperidinol, 1-ethyl-, diphenylacetate, hydrochloride
   * Piperidolate hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,97,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1040 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 104,269,1952
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,97,1969
 
                            *** END OF RECORD ***