*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AH2790000
CHEMICAL NAME           : Acetic acid, 2,2-diphenyl-2-ethoxy-,
                          (2-(dimethylamino)ethyl) ester, hydrochloride
CAS REGISTRY NUMBER     : 2424-75-1
LAST UPDATED            : 199012
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H25-N-O3.Cl-H
MOLECULAR WEIGHT        : 363.92
WISWESSER LINE NOTATION : 2OXR&R&VO2N1&1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetic acid, ethoxydiphenyl-, 2-(dimethylamino)ethyl ester hydrochloride
   * Aestocin
   * Benzeneacetic acid, alpha-ethoxy-alpha-phenyl-, 2-(dimethylamino)ethyl  
   ester hydrochloride
   * Dimenoxadol hydrochloride
   * Dimethylaminoethyl-diphenylethoxy acetate hydrochloride
   * beta'-Dimethylaminoethyl-alpha,alpha-diphenyl-alpha-ethoxyacetate  
   hydrochloride
   * 2,2-Diphenyl-2-ethoxyacetic acid (2-(dimethylamino)ethyl) ester  
   hydrochloride
   * Estocin
   * Estocine
   * Estotsin
   * Lokarin
   * Propalgyl
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 66 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 8,189,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 4,7,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 179 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 32,317,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,571,1965
 
                            *** END OF RECORD ***