*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AH0990000
CHEMICAL NAME           : Acetic acid,
                          2-(2-(dimethylamino)ethoxy)-2,2-diphenyl-,
                          2-(diethylamino)ethyl ester
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C24-H34-N2-O3
MOLECULAR WEIGHT        : 398.60
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Diethylaminoethyl diphenyl(dimethylaminoethoxy)acetate
   * 2-(2-(Dimethylamino)ethoxy)-2,2-diphenylacetic acid 2-(diethylamino)ethyl 
    ester
   * Ro 3-0131
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 12 mg/kg/7D-I
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - anorexia (human)
   Gastrointestinal - nausea or vomiting
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 6,634,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 475 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 6,634,1951
 
                            *** END OF RECORD ***