*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ8290000
CHEMICAL NAME           : Benzo(a)pyren-11-ol
CAS REGISTRY NUMBER     : 56892-32-1
BEILSTEIN REFERENCE NO. : 3332602
REFERENCE               : 3-06-00-03811 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C20-H12-O
MOLECULAR WEIGHT        : 268.32
WISWESSER LINE NOTATION : L D6 B6666 2AB TJ FQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benzo(a)pyrene, 11-hydroxy-
   * 11-Hydroxybenzo(a)pyrene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 82 mg/kg/38W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,2608,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 30 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   41,155,1982

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ABSYB2 Alfred Benzon Symposium.  (Nankodo Co. Ltd., POB 5272, Tokyo
   International 100-31, Japan) V.1-    1968-  Volume(issue)/page/year:
   10,261,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
   
   EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***