*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ8285000
CHEMICAL NAME           : Benzo(a)pyren-10-ol
CAS REGISTRY NUMBER     : 56892-31-0
BEILSTEIN REFERENCE NO. : 2464216
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C20-H12-O
MOLECULAR WEIGHT        : 268.32
WISWESSER LINE NOTATION : L D6 B6666 2AB TJ EQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benzo(a)pyrene, 10-hydroxy-
   * 10-Hydroxybenzo(a)pyrene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4280 ug/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CCSUDL Carcinogenesis--A Comprehensive Survey.  (Raven Press, 1185 Ave. of
   the Americas, New York, NY 10036)  V.1-    1976-  Volume(issue)/page/year:
   3,371,1978
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4290 ug/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,678,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 18600 pmol/L
REFERENCE :
   RRBCAD Revue Roumaine de Biochimie.  (Rompresfilatelia, POB 12-201,
   Bucharest, Romania) V.1-    1964-  Volume(issue)/page/year: 18(4),291,1981

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ABSYB2 Alfred Benzon Symposium.  (Nankodo Co. Ltd., POB 5272, Tokyo
   International 100-31, Japan) V.1-    1968-  Volume(issue)/page/year:
   10,261,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***