*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ5055900
CHEMICAL NAME           : Benzo(a)pyrene,
                          7-beta,8-alpha-dihydroxy-9-beta,10-beta-epoxy-7,8,9,1
                          0-tetrahydro-, (-)-cis
CAS REGISTRY NUMBER     : 63357-09-5
BEILSTEIN REFERENCE NO. : 4356683
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C20-H14-O3
MOLECULAR WEIGHT        : 302.34
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benzo(a)pyrene,  
   7,8,9,10-tetrahydro-7-alpha,8-beta-dihydroxy-9-alpha,10-alpha-epoxy-,  
   (-)-Z-
   * (-)-BP-7-beta,8-alpha-diol-9-beta,10-beta-epoxide 1
   *   (-)-cis-7-beta,8-alpha-Dihydroxy-9-beta,10-beta-epoxy-7,8,9,10-tetrahydr
     obenzo(a)pyrene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 ug/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,67,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 pmol/plate
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 77,1389,1977
 
TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 8 umol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,1081,1984
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 44,313,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat

 
                            *** END OF RECORD ***