*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ4990000
CHEMICAL NAME           : Benzo(a)pyrene, 4,5-dihydro-4,5-dihydroxy-, (E)-
CAS REGISTRY NUMBER     : 37571-88-3
LAST UPDATED            : 199410
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C20-H14-O2
MOLECULAR WEIGHT        : 286.34
WISWESSER LINE NOTATION : L D6 B6666 2AB T&&T&&J LQ MQ -E
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benzo(a)pyrene-4,5-dihydrodiol, (E)-
   * trans-4,5-Dihydro-4,5-dihydroxybenzo(a)pyrene
   * trans-4,5-Dihydrobenzo(a)pyrene-4,5-diol
   * trans-4,5-Dihydroxy-4,5-dihydrobenzo(a)pyrene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   34,523,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 30 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,839,1985
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 2 mg/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 74,1378,1977
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 1 mg/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 19,814,1977
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 8 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 50,367,1978
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 25 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,3350,1976

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ABSYB2 Alfred Benzon Symposium.  (Nankodo Co. Ltd., POB 5272, Tokyo
   International 100-31, Japan) V.1-    1968-  Volume(issue)/page/year:
   10,261,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
   
   EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test; In
   vitro SCE-nonhuman

 
                            *** END OF RECORD ***