*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ2885000
CHEMICAL NAME           : 2H-1-Benzopyran-3-ol,
                          3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)prop
                          oxy)-
CAS REGISTRY NUMBER     : 86247-86-1
LAST UPDATED            : 199212
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C15-H23-N-O4
MOLECULAR WEIGHT        : 281.39
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Denitronipradilol
   * 3,4-Dihydro-8-(2-hydroxy-3-(isopropylamino)propoxy)-2H-1-benzopyran-3-ol
   *   3,4-Dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2H-1-benzopyra
     n-3-ol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1840 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 29,725,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 141 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 29,725,1985
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21 gm/kg/5W-C
TOXIC EFFECTS :
   Endocrine - changes in adrenal weight
   Blood - hemorrhage
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 30,437,1985
 
                            *** END OF RECORD ***